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Important information

Vilazodone: CYP3A4 Inhibitors Strong may increase the serum concentration of Vilazodone. Ho TTY, Chan KCW, Wong KH et al. Abnormal fat distribution and use of protease inhibitors. Lancet. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

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Macitentan: CYP3A4 Inhibitors Strong may increase the serum concentration of Macitentan. PredniSONE: CYP3A4 Inhibitors Strong may increase the serum concentration of PredniSONE. Experts state ritonavir-boosted indinavir not recommended for initial treatment regimens in antiretroviral-naive pregnant women because of potential to cause kidney stones and hyperbilirubinemia. 202 In addition, data insufficient to recommend appropriate dosage of ritonavir-boosted indinavir for pregnant women.

Indinavir forms and strengths

Vemurafenib: CYP3A4 Inhibitors Strong may increase the serum concentration of Vemurafenib. Possibility of HIV resistance to indinavir and possible cross-resistance to other PIs. 1 Effect of indinavir therapy on subsequent therapy with other PIs under investigation. Eszopiclone: CYP3A4 Inhibitors Strong may increase the serum concentration of Eszopiclone. Management: Limit the eszopiclone dose to 2 mg daily when combined with strong CYP3A4 inhibitors and monitor for increased eszopiclone effects and toxicities eg, somnolence, drowsiness, CNS depression.

Indinavir brand names

Barbour TD, Furlong TJ, Finlayson RJ "Efavirenz-associated podocyte damage. Pimozide: CYP3A4 Inhibitors Strong may increase the serum concentration of Pimozide. There have been more than 60 reports of acute or chronic human overdosage up to 23 times the recommended total daily dose of 2400 mg with Crixivan. CHILDREN or before the patient's first menstrual period; safety and effectiveness in children have not been confirmed. Cardiovascular System: cardiovascular disorders including myocardial infarction and angina pectoris; cerebrovascular disorder.



CYP1A2, 2B6, 2C9, or 3A4

Cobimetinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Cobimetinib. Glaxo Wellcome, Research Triangle Park, NC: Personal communication. Concomitant use of trazodone and Crixivan may increase plasma concentrations of trazodone. Adverse events of nausea, dizziness, hypotension and syncope have been observed following coadministration of trazodone and ritonavir. If trazodone is used with a CYP3A4 inhibitor such as Crixivan, the combination should be used with caution and a lower dose of trazodone should be considered. Do not take alosetron if you are also taking fluvoxamine Luvox to treat obsessive-compulsive disorder. Consult your doctor before breast-feeding.



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Benperidol: CYP3A4 Inhibitors Strong may increase the serum concentration of Benperidol. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. What are the ingredients in ZERIT? HIV-infected adults. AIDS Clinical Trials Group protocols 150 and 258. Ann Intern Med. How often did hospital staff describe possible side effects in a way you could understand? Using dexamethasone together with indinavir may alter the effects of both medications. Contact your doctor if you experience thinning skin, easy bruising, changes in the shape or location of body fat especially in your face, neck, back, and waist increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. In addition, combining these medications can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Where can I get more information? St. John's wort, drugs used to treat such as phenytoin among others. Figures 5, 6, and 7, respectively. Corlanor ivabradine US prescribing information. Amgen, Inc. April 15, 2015. Hemophilia A or B: Use with caution in patients with hemophilia A or B; increased bleeding during protease inhibitor therapy has been reported. metaxalone



PI that require boosting

Immune reconstitution syndrome has occurred during combination antiretroviral therapy. Patients responding to therapy may develop an inflammatory response to indolent or residual opportunistic infections and require evaluation and treatment. TraZODone: Indinavir may increase the serum concentration of TraZODone. Management: Consider using a lower dose of trazodone when used in combination with indinavir. Some medicines can cause dangerous or life-threatening side effects when used with indinavir. Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach. Spontaneous bleeding episodes have been reported in hemophiliac patients while receiving protease inhibitors. No causal relationship has been established, however, hemophiliacs should be monitored closely for bleeding during protease inhibitor therapy. Clinically significant adverse reactions from greater exposures of Crixivan. Protease inhibitors may slow down how quickly your liver processes atorvastatin. Cobicistat is also a protease inhibitor. Piacenti FJ "An update and review of antiretroviral therapy. ekor.info diflucan



Common side effects of indinavir

Gerberding JL. Prophylaxis for occupational exposure to HIV. Ann Intern Med. Registry has been established. Advisory Council OARAC. NIH. National Institutes of Health "Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. When used without low-dose ritonavir in pregnant women, only minimal amounts of indinavir crossed the placenta. Vinflunine: CYP3A4 Inhibitors Strong may increase the serum concentration of Vinflunine. Check with your health care provider before you start, stop, or change the dose of any medicine. Increased serum triglycerides; increased serum cholesterol. Crixivan is an oral capsule used for the treatment of HIV Human Immunodeficiency Virus. HIV is the virus that causes AIDS acquired immune deficiency syndrome. Crixivan is a type of HIV drug called a protease PRO-tee-ase inhibitor. How does Crixivan work? ONGLYZA, a total of 4751 42. Szczech LA "Hypertension and medication-related renal dysfunction in the HIV-infected patient. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take three doses a day, the doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your doctor. ONGLYZA and metformin were not permitted. Qaqish RB, Fisher E, Rublein J, Wohl DA "HIV-associated lipodystrophy syndrome. Temsirolimus. Levels of sirolimus, the active metabolite, may be increased, likely due to inhibition of CYP-mediated metabolism. What happens if I miss a dose Lotronex?



Indinavir uses

Take this medication by mouth with a full glass of water 8 ounces or 240 milliliters on an empty stomach at least 1 hour before or 2 hours after food usually 3 times daily or as directed by your doctor. If upset stomach occurs, you may take it with other liquids such as non-fat milk, apple juice, coffee, tea or with a light meal such as dry toast with jelly, corn flakes with non-fat milk and sugar. Avoid taking this medication with a meal high in calories, fat, and protein since this may decrease its effect. If you are directed to take ritonavir with this medication, take them both at the same times. Cattelan AM, Trevenzoli M, Sasset L, Rinaldi L, Balasso V, Cadrobbi P "Indinavir and systemic hypertension. Significant accumulation was not observed after multiple dosing at 800 mg every 8 hours. Hypersensitivity to indinavir or any component of the formulation; coadministration with alfuzosin, amiodarone, ergot derivatives dihydroergotamine, ergonovine, ergotamine, methylergonovine lovastatin, simvastatin, cisapride, lurasidone, pimozide, oral midazolam, triazolam, alprazolam, and sildenafil when used for the treatment of pulmonary arterial hypertension. The recommended dose for adults is 800 mg every eight hours. Nilotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Nilotinib. Psychiatric side effects have included anxiety and neurosis. Depression has been reported during postmarketing experience. The amount of ivabradine in your blood may increase and cause your heart to slow down too much. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Read the Patient Information Leaflet if available from your before you start taking everolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Lexiva fosamprenavir calcium US prescribing information. The appropriate doses for this combination, with respect to efficacy and safety, have not been established. Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving Crixivan 800 mg q8h. Hypersensitivity: anaphylactoid reactions; urticaria; vasculitis. Vorapaxar: CYP3A4 Inhibitors Strong may increase the serum concentration of Vorapaxar. Prophylaxis should be initiated immediately, preferably within hours after exposure. pharmacy pantoprazole comp



Indinavir adult dosage

Kline MW, Fletcher CV, Harris AT et al. A pilot study of combination therapy with indinavir, stavudine d4T and didanosine ddI in children infected with the human immunodeficiency virus. J Pediatr. Some patients treated with Crixivan have had liver problems including liver failure and death. Some patients had other illnesses or were taking other drugs. It is uncertain if Crixivan caused these liver problems. While on these medicines, you will need an alternative form of birth control eg, condoms until your next period after stopping these medicines. Tacrolimus Systemic: Protease Inhibitors may decrease the metabolism of Tacrolimus Systemic. Hutchinson A, Murphy M, Harries R, Skinner CJ "Galactorrhoea and hyperprolactinaemia associated with protease-inhibitors. Of the indinavir resistant HIV-1 isolates, 63% showed resistance to saquinavir and 81% to amprenavir. You are pregnant or if you become pregnant while you are taking Crixivan. We do not yet know how Crixivan affects pregnant women or their developing babies. Yeh KC, Deutsch PJ, Haddix H et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. cefdinir dinner



Does indinavir interact with other medications

New onset or exacerbation of preexisting diabetes mellitus, glucose intolerance, and hyperglycemia have been reported during postmarketing surveillance in HIV patients treated with protease inhibitors PIs. Frequently, insulin resistance may accompany fat redistribution and serum lipid elevations in what is collectively termed the HIV-associated lipodystrophy syndrome. Although a causal relationship has not been established, these metabolic disturbances have most often occurred in HIV patients during treatment with potent antiretroviral regimens containing PIs. Patients with or predisposed to glucose disorders should be monitored during PI therapy. Dosage adjustments in insulin or oral hypoglycemic medications may be necessary in patients with diabetes. In some cases, glucose abnormalities persisted despite discontinuation of PI therapy. Fauci AS. AIDS in 1996: much accomplished, much to do. JAMA. Lovastatin: Protease Inhibitors may increase the serum concentration of Lovastatin. Hirsch M, Steigbigel R, Staszewski S et al. A randomized, controlled trial of indinavir, zidovudine, and lamivudine in adults with advanced human immunodeficiency virus type 1 infection and prior antiretroviral therapy. J Infect Dis. Gulick RM, Mellors JW, Havlir D et al. Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up. JAMA. Babesiosis off-label use: Oral: 750 mg twice daily with azithromycin for 7 to 10 days; Note: Relapsing infection may require at least 6 weeks of therapy Krauss 2000; Vannier 2012. Agouron Pharmaceuticals, La Jolla, CA: Personal communication.



Indinavir dosage

Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. In vitro phenotypic susceptibilities to indinavir were determined for 38 viral isolates from 13 patients who experienced virologic rebounds during indinavir monotherapy. CYP3A4 Inducers Moderate: May decrease the serum concentration of CYP3A4 Substrates. Alfuzosin: Protease Inhibitors may increase the serum concentration of Alfuzosin. St. John's wort is not recommended. Desbois D, Roquebert B, Peytavin G et al. In vitro phenotypic susceptibility of human immunodeficiency virus type 2 clinical isolates to protease inhibitors. Antimicrob Agents Chemother. Indinavir with or without low-dose ritonavir not recommended for initial treatment regimens in antiretroviral-naive pediatric patients because of high incidence of hematuria, sterile leukocyturia, and nephrolithiasis in children. Miller KD, Jones E, Yanovski JA et al. Visceral abdominal-fat accumulation associated with use of indinavir. Lancet. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take three doses a day, the doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your doctor. escitalopram buy online store



Side effects of indinavir

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. If motor weakness develops, ZERIT should be discontinued. Grases F, Garcia-Gonzalez R, Redondo E, et al. "Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. Hyperbilirubinemia: Indirect hyperbilirubinemia has been observed frequently and has infrequently been associated with serum transaminase elevations. Do not use concurrently with atazanavir. Do not skip pills even if you are spotting or bleeding between monthly periods or feel sick to your stomach nausea. Levobupivacaine: CYP3A4 Inhibitors Strong may increase the serum concentration of Levobupivacaine. Do not take Crixivan if you have had a serious allergic reaction to Crixivan or any of its components. What other medical problems or conditions should I discuss with my doctor? When indinavir is taken with delaviridine, levels of indinavir may increase. This may cause pain in your side, blood in your urine, nausea, vomiting, or diarrhea. Panobinostat: CYP3A4 Inhibitors Strong may increase the serum concentration of Panobinostat. Management: Reduce the panobinostat dose to 10 mg when it must be used with a strong CYP3A4 inhibitor. Gariano RF, Cooney EL. Uveitis following administration of the protease inhibitor indinavir to a patient with AIDS. Clin Inf Dis. Bristol-Myers Squibb. Reyataz atazanavir sulfate capsules prescribing information. Princeton, NJ; 2012 Mar. Psychiatric: oral paresthesia; depression. Indinavir is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor. cipro



About indinavir

II evaluation of the HIV protease inhibitor MK-639 indinavir. AIDS. Concomitant ketoconazole: Dose reduction of indinavir to 600 mg orally every 8 hours is recommended. Check with your pharmacist about how to dispose of unused medicine. Mild to moderate hepatic impairment due to cirrhosis: 600 mg every 8 hours. Plasma concentrations may be increased by CRIXIVAN. ONGLYZA and periodically thereafter. DPP4 inhibitor, which is one-half as potent as saxagliptin. Boceprevir: May decrease the serum concentration of Protease Inhibitors. Protease Inhibitors may decrease the serum concentration of Boceprevir. Management: Some combinations are not recommended. See full drug interaction monograph for details. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Zuclopenthixol: CYP3A4 Inhibitors Strong may increase the serum concentration of Zuclopenthixol. Management: Consider zuclopenthixol dosage reduction with concomitant use of a strong CYP3A4 inhibitor eg, ketoconazole in poor CYP2D6 metabolizers or with strong CYP2D6 inhibitors eg, paroxetine.



Use of indinavir

Check with your doctor right away if you have blood in your urine, nausea and vomiting, pain in the groin or genitals, or sharp back pain just below the ribs. Take this by with a full glass of water 8 ounces or 240 milliliters on an empty at least 1 hour before or 2 hours after food usually 3 times daily or as directed by your doctor. If occurs, you may take it with other liquids such as non- milk, apple juice, coffee, tea or with a light meal such as dry toast with jelly, corn flakes with non-fat milk and sugar. Avoid taking this medication with a meal high in calories, fat, and protein since this may decrease its effect. If you are directed to take with this medication, take them both at the same times. Included as part of the PRECAUTIONSsection. Maraviroc: CYP3A4 Inhibitors Strong may increase the serum concentration of Maraviroc. Management: Reduce the adult dose of maraviroc to 150 mg twice daily when used with a strong CYP3A4 inhibitor. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, and QT prolongation see above. Viracept nelfinavir mesylate US prescribing information. Fletcher cv, Brundage RC, Remmel RP et al. Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy. Antimicrob Agents Chemother. fluticasone



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Indications and usage of indinavir


What other drugs will affect indinavir

Dose reduction of Crixivan to 600 mg every 8 hours is recommended when administering ketoconazole concurrently. Methadone: Administration of indinavir 800 mg every 8 hours with methadone 20 mg to 60 mg daily for one week in subjects on methadone maintenance resulted in no change in methadone AUC. Based on a comparison to historical data, there was little or no change in indinavir AUC. Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates. Maness LJ, Blair DC, Newman N, Coyle TE "Elevation of platelet counts associated with indinavir treatment in human immunodeficiency virus-infected patients.

ONGLYZA did not increase over time

CDC 1982; some data suggests that benzoate displaces bilirubin from protein binding sites Ahlfors 2001; avoid or use dosage forms containing benzyl alcohol with caution in neonates. ZERIT in study AI455-019. Take your next dose at the regular time. This means you may take 2 doses on the same day. You do not need to use a backup method of birth control if you only miss 1 pill. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

It may harm them

Check with your healthcare provider. DOXOrubicin Conventional: CYP3A4 Inhibitors Strong may increase the serum concentration of DOXOrubicin Conventional. Management: Seek alternatives to strong CYP3A4 inhibitors in patients treated with doxorubicin whenever possible. Everolimus may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. Valbenazine: CYP3A4 Inhibitors Strong may increase the serum concentration of Valbenazine. Management: Reduce the valbenazine dose to 40 mg daily when combined with strong CYP3A4 inhibitors.

Indinavir side effects

MethylPREDNISolone: CYP3A4 Inhibitors Strong may increase the serum concentration of MethylPREDNISolone. Management: Consider methylprednisolone dose reduction in patients receiving strong CYP3A4 inhibitors and monitor for increased steroid related adverse effects. Glesby MJ, Aberg JA, Kendall MA, et al. "Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers. Hemolytic anemia: Has been associated with acute hemolytic anemia, sometimes fatal; discontinue if hemolytic anemia occurs. Rodwell GEJ, Maurer TA, Barger TG "Fat redistribution in HIV disease.

Use indinavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. PCP were eligible for enrollment. Levomilnacipran: CYP3A4 Inhibitors Strong may increase the serum concentration of Levomilnacipran.

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